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Exam 1: Cytoplasm

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Question 21

Multiple Choice

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A 9-month-old female Jewish baby, whose parents were born in Poland, is seen by her pediatrician because of neurologic problems, including generalized paralysis and blindness. The pediatrician should suspect that the child is suffering from

A) spina bifida
B) cranial nerve X (vagus nerve) disorder
C) Tay-Sachs disease
D) Fabry's disease
E) Refsum's disease

F) D) and E)
G) A) and E)

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Question 22

Multiple Choice

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Acid hydrolases are synthesized on the rough endoplasmic reticulum and are delivered to the Golgi complex to be packaged and distributed to their final destination. In patients whose protooncogenes have mutated to form ras protein-related products known as ADP-ribosylation factor (ARF) , this factor may interfere with

A) coatomer II (COP II) synthesis
B) coatomer II (COP II) assembly
C) coatomer II (COP II) dissociation from vesicles
D) clathrin synthesis
E) clathrin assembly

F) D) and E)
G) None of the above

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Question 23

Multiple Choice

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A neonatal baby boy is observed to have malformed hands, feet, and skull. Additional examination displays jaundice, hepatomegaly, and hypotonic muscles with psychomotor retardation. The pediatrician diagnoses the disorder as cerebrohepatorenal syndrome (Zellweger's syndrome) . This condition is due to problems with which of the following organelles?

Early in the morning, a male patient sees his physician because he and his wife have been trying to start a family. According to the patient, his wife was told that she is able to become pregnant, and he wants to have the physician check him for sterility. The physician notices that the patient has a heavy cough. Upon questioning, the patient reveals that he also coughs in the evening, produces a lot of sputum, and has had numerous colds and even occasional pneumonia. The doctor asks for a sperm sample but already is thinking of a possible diagnosis of Kartagener's syndrome, a genetic disorder that affects