Question 1

Many viruses reduce the amount of MHC-I complex on the surface of the infected cell.How does the immune system recognize cells that lack MHC-I?

Accepted Answer

A)   Cytotoxic T lymphocytes will recognize the lack of MHC-I on the surface and kill the cell
B)   Macrophages will recognize an antibody bound to MHC-I and engulf the cell.
C)   Natural killer cells will kill cells that lack MHC-I on their surface.
D)   Cells that don't have enough MHC-I on their surface will enter apoptosis and die.
E)   Cytotoxic T lymphocytes will recognized the altered MHC-I on the cell surface.F) A) and C)
G) A) and E)

Question 2

A single plasma cell can secrete two different antibodies that recognize different epitopes.

Accepted Answer

A) True 
 B)False

Question 3

Which of the following describes the primary role of Th1 cells in modulating the immune response?

Accepted Answer

A)   They present foreign antigens to B and T cells.
B)   They engulf virus particles and present peptides on MHC-II.
C)   They release cytokines that stimulate differentiation of cytotoxic T cells.
D)   They release cytokines that stimulate a B cell to differentiate into a plasma cell.
E)   They recognize and kill virus infected cells.F) A) and D)
G) C) and D)

Question 4

The IgG molecule is the most abundant immunoglobulin produced during an immune response.

Accepted Answer

A) True 
 B)False

Question 5

Explain how B and T lymphocytes produced a variety of cell surface receptors that can bind a wide variety of epitopes on antigens.How is this related to the clonal selection theory?

Accepted Answer

There are two polypeptides that compose ...

Question 6

Which of the following is NOT an antigen presenting cell?

Accepted Answer

A)   Cytotoxic T lymphocyte
B)   Macrophage
C)   Dendritic cell
D)   B lymphocyte
E)   All of the above are antigen presenting cells.F) B) and C)
G) B) and E)

Question 7

Which of the following is NOT a peripheral or secondary lymphoid organ?

Accepted Answer

A)   Tonsils
B)   Thymus
C)   Lymph node
D)   Spleen
E)   Peyer's patchesF) None of the above
G) A) and B)

Question 8

Which of the following is NOT a component of the innate immune response system?

Accepted Answer

A)   Cytotoxic T lymphocytes
B)   Complement system
C)   Natural killer cells
D)   Polymorphonuclear leukocytes
E)   MacrophagesF) C) and E)
G) B) and C)

Question 9

Which of the following statements about MHC class I molecules is FALSE?

Accepted Answer

A)   They are located on the surface of all cells in the body.
B)   They are used to identify the cells as belonging to the host (self-identification) .
C)   They are recognized by natural killer cells.
D)   They present cytoplasmic peptides to cytotoxic T lymphocytes.
E)   They are recognized by B lymphocytes.F) None of the above
G) A) and E)

Question 10

Antibodies are produced by CD4 positive T lymphocytes.

Accepted Answer

A) True 
 B)False

Question 11

What happens when the T cell receptor on a CD8 positive T cell recognizes the peptide displayed in the MHC-I complex on an infected cell?

Accepted Answer

A)   It attracts natural killer cells, which kill the infected cell.
B)   It releases interferon g which stimulates macrophages to engulf the cell.
C)   It releases IL-4 to stimulate the B cells to release antibodies.
D)   It releases proteins that kill the infected cell.
E)   It releases IL-12 which stimulates the production of Th1 cells.F) A) and D)
G) A) and C)

Question 12

Which of the following is the receptor that differentiates a cytotoxic T lymphocyte from a helper T lymphocyte?

Accepted Answer

A)   CD8 receptor
B)   CD4 receptor
C)   MHC class I
D)   T cell receptor
E)   B cell receptorF) A) and B)
G) C) and E) A

Question 13

Which of the following events causes a naïve T lymphocyte to become activated and differentiate into an effector T cell?

Accepted Answer

A)   The T cell receptor recognizes its epitope on a peptide presented on MHC-I.
B)   The T cell receptor recognizes its epitope on a peptide presented on MHC-II
C)   A T helper cell releases IL-12 and causes it to differentiate.
D)   A macrophage releases IL-4 and causes it to differentiate.
E)   The T cell interacts with a B cell that recognizes the same epitope.F) A) and D)
G) B) and D)

Question 14

Pathogen specific B and T lymphocytes are mostly localized in specialized organs of the lymphatic system.

Accepted Answer

A) True 
 B)False  True

Question 15

Which of the following is NOT an activity associated with interferon g?

Accepted Answer

A)   Induces the expression of MHC class II proteins.
B)   Enhances the processing of viral proteins into peptides.
C)   Induces the differentiation of natural killer cells.
D)   Stimulates development of Th1 cells.
E)   Stimulates activation of macrophages.F) A) and B)
G) A) and C)

Question 16

Which of the following describes the process of antibody-dependent cellular cytotoxicity?

Accepted Answer

A)   An antibody activates the Fas receptor on the infected cell and causes it to enter apoptosis.
B)   An antibody causes the virus to be killed by a cytotoxic T lymphocyte.
C)   An antibody binds to a virus particle and it is engulfed by a macrophage.
D)   An antibody binds to a virally infected cell and it is attacked by a macrophage.
E)   Both "c" and "d" are correctF) None of the above
G) A) and D) E

Question 17

The constant region of an antibody molecule is only located on the light chain.

Accepted Answer

A) True 
 B)False

Question 18

Which of the following is NOT a component of the adaptive immune response system?

Accepted Answer

A)   B lymphocytes
B)   Helper T lymphocytes
C)   Cytotoxic T lymphocytes
D)   Complement system
E)   AntibodiesF) B) and D)
G) B) and C)

Question 19

Antigen presenting cells, like dendritic cells, interact with naïve T and B lymphocytes in the lymph nodes.

Accepted Answer

A) True 
 B)False

Question 20

Which of the following is a situation where an NK cell can recognize a virally infected cell and kill it?

Accepted Answer

A)   The plasma membrane contains viral glycoproteins.
B)   The NK cell recognizes the MHC-I complex on the surface.
C)   The infected cell displays peptides on MHC-I complexes on its surface
D)   The infected cell has a reduced amount of MHC proteins on its surface.
E)   The NK cell recognizes the virus host cell receptor on the surface of the cell.F) C) and D)
G) B) and C)

Exam 34: Innate and Adaptive Immune Responses to Virus Infection

Many viruses reduce the amount of MHC-I complex on the surface of the infected cell.How does the immune system recognize cells that lack MHC-I?

Correct AnswerverifiedShow Answer

A single plasma cell can secrete two different antibodies that recognize different epitopes.

Correct AnswerverifiedShow Answer

Which of the following describes the primary role of Th1 cells in modulating the immune response?

Correct AnswerverifiedShow Answer

The IgG molecule is the most abundant immunoglobulin produced during an immune response.

Correct AnswerverifiedShow Answer

Explain how B and T lymphocytes produced a variety of cell surface receptors that can bind a wide variety of epitopes on antigens.How is this related to the clonal selection theory?

Correct AnswerverifiedThere are two polypeptides that compose ...View AnswerShow Answer

Which of the following is NOT an antigen presenting cell?

Correct AnswerverifiedShow Answer

Which of the following is NOT a peripheral or secondary lymphoid organ?

Correct AnswerverifiedShow Answer

Which of the following is NOT a component of the innate immune response system?

Correct AnswerverifiedShow Answer

Which of the following statements about MHC class I molecules is FALSE?

Correct AnswerverifiedShow Answer

Antibodies are produced by CD4 positive T lymphocytes.

Correct AnswerverifiedShow Answer

What happens when the T cell receptor on a CD8 positive T cell recognizes the peptide displayed in the MHC-I complex on an infected cell?

Correct AnswerverifiedShow Answer

Which of the following is the receptor that differentiates a cytotoxic T lymphocyte from a helper T lymphocyte?

Correct AnswerverifiedA

Which of the following events causes a naïve T lymphocyte to become activated and differentiate into an effector T cell?

Correct AnswerverifiedShow Answer

Pathogen specific B and T lymphocytes are mostly localized in specialized organs of the lymphatic system.

Correct AnswerverifiedTrue

Which of the following is NOT an activity associated with interferon g?

Correct AnswerverifiedShow Answer

Which of the following describes the process of antibody-dependent cellular cytotoxicity?

Correct AnswerverifiedE

The constant region of an antibody molecule is only located on the light chain.

Correct AnswerverifiedShow Answer

Which of the following is NOT a component of the adaptive immune response system?

Correct AnswerverifiedShow Answer

Antigen presenting cells, like dendritic cells, interact with naïve T and B lymphocytes in the lymph nodes.

Correct AnswerverifiedShow Answer

Which of the following is a situation where an NK cell can recognize a virally infected cell and kill it?

Correct AnswerverifiedShow Answer

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There are two polypeptides that compose ...
View Answer

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A

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True

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E

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