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When chemically-gated Na+ channels open, the membrane


A) hyperpolarizes
B) repolarizes
C) depolarizes
D) becomes more negative
E) is inhibited

F) None of the above
G) A) and C)

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Which of the following is responsible for the falling phase of an action potential?


A) opening of Na+ gates
B) Na+-K+ pump restoring the ions to their original locations
C) greatly increased permeability to Na+
D) ATP-ase destroying the energy supply that was maintaining the action potential at its peak
E) none of these

F) A) and E)
G) All of the above

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The nucleus of a neuron is housed in the


A) axon
B) axon hillock
C) cell body
D) collaterals
E) dendrites

F) C) and D)
G) A) and E)

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An action potential on a neuron develops when


A) threshold voltage is reached on an axon
B) voltage-gated Na+ channels open
C) spatial and/or temporal summation of graded potentials occurs to a great enough degree
D) the axon hillock reaches threshold
E) all of these

F) A) and E)
G) D) and E)

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Select the incorrect statement about the action potential.


A) It has an all-or-none characteristic.
B) It has a refractory period.
C) It is triggered by depolarization to threshold.
D) It occurs along a plasma membrane.
E) It speeds up transmission by summation.

F) All of the above
G) A) and E)

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The grand postsynaptic potential depends on the sum of activity of the presynaptic inputs.

A) True
B) False

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A change in a membrane potential from -70 mV to -60mV is an example of


A) depolarization
B) hyperpolarization
C) polarization
D) repolarization
E) zero potential

F) A) and E)
G) A) and D)

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Neuron A and neuron B release a minimal amount of neurotransmitter simultaneously onto neuron C, causing neuron C to experience an action potential. This is an example of


A) temporal summation
B) spatial summation
C) convergence
D) temporal summation and convergence
E) spatial summation and convergence

F) C) and D)
G) A) and C)

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The passive current flow of a graded potential fades quickly.

A) True
B) False

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Spatial summation occurs in a postsynaptic neuron


A) when several EPSPs from a single presynaptic input sum to reach threshold
B) when EPSPs from several presynaptic inputs sum to reach threshold
C) upon simultaneous interaction of an EPSP and an IPSP
D) when several IPSPs from a single presynaptic input sum to hyperpolarize the membrane
E) none of these

F) B) and D)
G) None of the above

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Graded potentials


A) are local changes in membrane potential that occur in varying degrees of magnitude
B) serve as short-distance signals
C) serve as long-distance signals
D) are local changes in membrane potential that occur in varying degrees of magnitude, and serve as short-distance signals
E) are local changes in membrane potential that occur in varying degrees of magnitude, and serve as long-distance signals

F) B) and E)
G) C) and E)

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Multiple sclerosis is an autoimmune disease in which the body's defense system erroneously attacks the myelin sheath surrounding myelinated nerve fibers.

A) True
B) False

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Neuropeptides


A) are sometimes co-secreted along with classical neurotransmitters
B) are synthesized in the cytosol of the axon terminal
C) act at the subsynaptic membrane of the postsynaptic neuron
D) all of these
E) are sometimes co-secreted along with classical neurotransmitters and are synthesized in the cytosol of the axon terminal

F) A) and D)
G) A) and B)

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Complete each of the following statments. Intentional, programmed cell death is called ____________________.

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Select the neuropeptide.


A) acetylcholine
B) dopamine
C) epinephrine
D) cholecystokinin
E) glycine

F) C) and D)
G) A) and B)

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During the absolute refractory period, the voltage-gated Na+ channels are not capable of opening again in response to another triggering event.

A) True
B) False

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Complete each of the following statments. Axons can range in length from less than a millimeter to over one ____________________.

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Nerve fiber is another name for a dendrite on a neuron.

A) True
B) False

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Tetanus toxin


A) combines with glycine receptors, thus blocking the action of this inhibitory neurotransmitter
B) destroys dopamine in the region of the brain involved in controlling complex movements
C) prevents the release of GABA onto inputs terminating on neurons that supply skeletal muscles
D) promotes presynaptic facilitation
E) causes retrograde flow in axon

F) A) and D)
G) A) and C)

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During the rising phase of the action potential:


A) PK+ is much greater than PNa+.
B) PNa+ is much greater than PK+.
C) PK+ is the same as P Na+.
D) Na+ efflux occurs.
E) PNa+ is much greater than PK+, and Na+ efflux occurs.

F) A) and E)
G) D) and E)

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